Highly Stereoselective Intermolecular Oxy-Michael Addition Reaction to α,β-Unsaturated Malonate Esters
- 1 April 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (9) , 1357-1360
- https://doi.org/10.1021/ol049820x
Abstract
The highly diastereoselective oxy-Michael addition of the “naked” anion of (6S)-methyl δ lactol to alkylidiene-, arylidene-, and heteroarylidenemalonate derivatives leading to the direct formation of THP*-protected β-hydroxy ester derivatives is described. Subsequent acid-mediated deprotection affords the enantioenriched aldol products in quantitative yields.Keywords
This publication has 1 reference indexed in Scilit:
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