NEW EVIDENCES FOR PARTICIPATION OF BIOGENIC MONO-AMINES IN ANDROGEN-DEPENDENT SEXUAL-DIFFERENTIATION OF HYPOTHALAMIC CONTROL OF GONADOTROPIN-SECRETION IN RATS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 73  (1) , 11-19
Abstract
Corpora lutea were found in the ovarian tissue transplanted into the anterior ocular chamber of castrated 2 mo. old male rats receiving on 3rd through 7th post-natal days .alpha.-methyl-p-tyrosine or p-chlorophenylalanine. Administration of these agents in combination with testosterone propionate to newborn female rats prevented essentially development of the anovulatory syndrome and maintained a normal picture of vaginal smears, ovarian and uterine structure as well as cyclic changes of adenohypophyseal and blood plasma lutropin contents and normal levels of estradiol and progesterone in the blood plasma except of progesterone level in animals receiving .alpha.-methyl-p-tyrosine. The preventive effect of the adrenoblocking agents droperidol and propranolol was weak and inconstant. Catecholamines and serotonin may participate in the androgen-dependent sexual differentiation of the brain in rats.

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