Action of Aureomycin and Chloromycetin on the Virus of Primary Atypical Pneumonia.

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Abstract
Aureomycin injected intraperit. starting 24 hrs. after intranasal infection of cotton rats with the virus of primary atypical pneumonia almost completely inhibits the development of pulmonary consolidation when given in daily doses of 1 mg., and is partly active at a dosage of 0.5 mg./day. Therapeutic activity with doses of 2-5 mg. daily was also demonstrable when the beginning of treatment was delayed for 5-6 days. Chloromycetin in doses of 5-20 mg./day had slight and irregular effects on the virus in cotton rats under the same exptl. conditions. Aureomycin inhibits the growth of the atypical pneumonia virus in thick embryos when injected in the yolk sac in 2 doses of 1 mg. each, 2 and 48 hrs. after amniotic inoculation of the virus.