Sendai virus causes a rise in intracellular free Ca2+ before cell fusion

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Abstract
1. Sendai virus caused a large increase in the concentration of free Ca2+ within human erythrocyte ghosts detected by the Ca2+-activated photoprotein obelin. 2. The increase in intracellular [Ca2+] preceded fusion. However, fusion could also be observed in the absence of a detectable rise in intracellular free [Ca2+]. 3. It was concluded that the increase in intracellular free [Ca2+] was not an absolute requirement for cell fusion, but may be necessary to produce fusion at the maximum rate.