The effect of selective α1- and α2-adrenoceptor stimulation on intraocular pressure in the conscious rabbit
- 1 July 1981
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 316 (4) , 294-298
- https://doi.org/10.1007/bf00501360
Abstract
The influence of topically applied selective α1- and α2-adrenoceptor agonists on intraocular pressure and the diameter of the pupil was investigated in conscious rabbits. Selective stimulation of the α1-subtype of receptors induced an elevation in intraocular pressure, accompanied by mydriasis, whereas stimulation of the α2-subtype caused a marked and dose-dependent ocular hypotensive response, which was blocked by the selective α2-adrenoceptor antagonist yohimbine. α2-Agonists induced neither macroscopic ocular side effects, nor an effect on the pupil size. Possibly, the subclass of α2-adrenoceptor stimulating drugs represent a group of new antiglaucomatous agents.Keywords
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