EFFECT OF HISTAMIN ON GASTRIC SECRETION

17 January 1925

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 84 (3) , 158-161
https://doi.org/10.1001/jama.1925.02660290002002

Abstract

Histamin has a markedly stimulating effect on gastric secretion. This action of the drug on cats and dogs was observed by Popielski,¹Keeton, Koch and Luckhardt,²Lim,³Rothlin and Gundlach,⁴and Ivy, McIlvain and Javois,⁵and the same observation was made on the stomach of man by Carnot, Koskowski and Libert,⁶and by Matheson and Ammon.⁷By subcutaneous injection of the drug and periodic aspiration of t[ill] gastric contents, Matheson and Ammon found that there was an increased flow of gastric juice accompanied by an increase of free hydrochloric acid, total acidity and peptic activity. In this study, the effect of histamin on gastric secretion was observed in seventeen subjects, of whom six were normal. The remaining eleven had presented achlorhydria in a single fractional test meal (arrowroot crackers, 40 gm., and water, 400 c.c.), with aspirations at fifteen-minute intervals during the second

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