Changes in benzodiazepine receptors in alzheimer‐type dementia
- 1 April 1988
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 23 (4) , 404-406
- https://doi.org/10.1002/ana.410230419
Abstract
We studied benzodiazepine receptors in brains obtained at autopsy from 7 normal controls and 7 patients with Alzheimer-type dementia, using 3H-flunitrazepam as a ligand. Compared with controls, 3H-flunitrazepam binding sites were significantly reduced in number in frontal and temporal cortex and hippocampus in the Alzheimer-type dementia brains. These results suggest that there are significant changes in the number of benzodiazepine receptors in selected brain regions of patients with Alzheimer-type dementia.This publication has 16 references indexed in Scilit:
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