Pattern of Primary Resistance of Helicobacter pylori to Metronidazole or Clarithromycin in the United States

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Abstract
ANTIBIOTIC treatment of Helicobacter pylori infection is complex, requiring multiple antibiotics combined with acid suppressive agents to ensure high cure rates. Treatment failure is attributed generally to the lack of compliance with the drug regimen or to acquired antibiotic resistance of the organism.1,2 Emergence of resistant H pylori has been documented in various countries and threatens to compromise current treatment regimens.1-12 However, data on resistance are generally obtained from unique subsets of populations over a short period. There are few data regarding the resistance rates in the United States.