Angiotensin II Responses of Rabbit Aortic Strips Compared with Fast and Slow Epinephrine Responses

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Abstract
Epinephrine causes a biphasic contraction of rabbit aorta, consisting of a fast component, F, ascribed to release of intracellular Ca and a slow component, S, ascribed to Ca movement into the muscle cell. Angiotensin produces a single-phase contraction of uncertain Ca source. Insight into the latter may be obtained if angiotensin contractions consistently resembled the F or S epinephrine response. Contractions of rabbit aorta strips produced by both drugs were therefore compared during 5 interventions which had dissociated effects on F or S epinephrine responses. These interventions consistently altered the angiotensin responses in the same way as they affected epinephrine F responses and differently from their effects on epinephrine S responses. The view is supported that the likely major source of activator Ca for angiotensin-induced contractions of rabbit aorta is intracellular, although a small extracellular Ca contribution could not be excluded.

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