Origin of colorectal cancers in hyperplastic polyps and serrated adenomas: another truism bites the dust.

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Abstract
Colorectal carcinoma is the second most common cause of cancer deaths in the United States (1), and on average approximately six people die every hour of every day as a result of this malignancy. Because these tumors are so frequent and so obvious on the mucosal surface of the large bowel, their morphogenesis has attracted great attention over the centuries (2). The evolution of understanding of the pathogenesis of colorectal cancer in recent years is nothing short of remarkable, especially during the era of molecular pathology. The article by Hawkins and Ward (3) in this issue of the Journal contributes to that evolution.

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