In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound.
- 1 July 1997
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 204 (1) , 263-268
- https://doi.org/10.1148/radiology.204.1.9205257
Abstract
Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed-focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.Keywords
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