Familial Insulin Resistance with Acanthosis Nigricans, Acral Hypertrophy, and Muscle Cramps

Publisher Website
Google Scholar
Abstract
RESISTANCE of the target cell to insulin action coexists with the skin lesion acanthosis nigricans in several distinct clinical syndromes.1 The Type A syndrome of insulin resistance, in which insulin resistance and acanthosis nigricans occur together with polycystic ovaries in young females, is one example.1 , 2 Receptors for insulin were reduced in concentration on circulating monocytes in three of the first four patients studied.2 , 3 Because insulin resistance can be clinically silent and acanthosis nigricans is often not observed, the incidence of this syndrome is unknown. Fundamental aspects of the disorder that remain unexplored include the cause of the receptor (or postreceptor) . . .