Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for α-synuclein
- 1 September 1998
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 51 (3) , 887-889
- https://doi.org/10.1212/wnl.51.3.887
Abstract
In familial PD, a mutation of the α-synuclein gene has been identified. α-Synuclein also was revealed in Lewy bodies in idiopathic PD. Lewy bodies in neurodegeneration with brain iron accumulation type 1(NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for α-synuclein/precursor of non-A beta component of Alzheimer9s disease amyloid, indicating that α-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.Keywords
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