Genetic epidemiology of twinning: A population-based study

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Abstract
We report on kinship analysis of mothers with twins and a study of their ancestors and inbreeding. A pair‐matched case‐control design supports the analyses. Nearly as high a number of ancestors was found at the origin of cases as in control individuals. Study cases were less inbred than control subjects, but their kinship was higher, especially for unlike‐sex twins born after age 30 years. The results indicate a genetic origin of both types of twins and possibly a highly spread gene with dominant or co‐dominant expression.