Tumor Growth in the Guinea Pig: Alpha Globulin Changes Associated With Lymphocyte Suppression 2

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Abstract
Serum globulin changes associated with tumor growth and suppressed Iymphocyte responsiveness to mitogen stimulation were observed in strain-13 guinea pigs. Disc gel electrophoresis of serum hal'vested during growth of a transplanted, 3-methylcholanthrene-induced fibrosarcoma showed an increase in globulin fraction 4 in the α-globulin region. Globulin fraction 4 significantly rose by 16 days of tumor growth and remained elevated until the animals died. Concomitant with this increase, in vitro suppression of Iymphocyte reactivity to phytohemagglutinin and pokeweed mitogen was observed. Inhibition, measured by the level of 3H-thymidine incorporated into whole blood cultures, increased in severity until death of the animals. Direct correlations between progressive tumor growth, suppression of cell-mediated tumor immunity, and increases in disc gel fraction 4 were observed.

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