Repeated exercise regulates glucose transport capacity in skeletal muscle

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Abstract
The present study was undertaken to test the hypothesis that a muscle's habitual level of contractile activity might act as a long‐term regulator of glucose transport capacity. Rats were rendered severely diabetic by injection of streptozotocin, 125 mg kg‐1 body wt. Three days after the injection, insulin‐stimulated and contraction‐induced 3‐methylglucose transport in the in vitro epitrochlearis muscle preparation was reduced to 25% and 52% of control capacity, respectively (P < 0.001). However, when repeated i‐h swimming sessions (twice a day) were introduced during the 3 days of insulin deficiency, the reduction in contraction‐induced glucose transport capacity was completely abolished. This indicates that the habitual level of contractile activity of a muscle regulates its capacity for exercise‐stimulated glucose transport. Furthermore, one exercise session and a maximal insulin stimulus had an additive effect on 3‐methylglucose transport, suggesting that there are two pools of intracellular glucose transporters or two mechanisms for mobilizing the same pool.

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