From head to toes: the multiple facets of Sox proteins
- 15 March 1999
- journal article
- review article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 27 (6) , 1409-1420
- https://doi.org/10.1093/nar/27.6.1409
Abstract
Sox proteins belong to the HMG box superfamily of DNA-binding proteins and are found throughout the animal kingdom. They are involved in the regulation of such diverse developmental processes as germ layer formation, organ development and cell type specifi-cation. Hence, deletion or mutation of Sox proteins often results in developmental defects and congenital disease in humans. Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other.Keywords
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