Effect of Prednison Therapy on Serum Levels of Thyroxine (T4), Triiodothyronine (T3), Reverse Triiodothyronine (rT3), T3-Binding Capacity, Basal TSH Level and TSH Response to Thyreoliberin (TRH) in Children
- 1 April 1985
- journal article
- research article
- Published by Georg Thieme Verlag KG in Experimental and Clinical Endocrinology & Diabetes
- Vol. 85 (02) , 191-198
- https://doi.org/10.1055/s-0029-1210435
Abstract
Effects of Prednison therapy on serum levels of T4, T3, rT3, TBC, basal TSH and TSH response to TRH in 10 children (7 with nephrotic syndrome, 3 with trombocytopenia) were studied.× It has been found out that corticotherapy (Prednison 1 — 2 mg/kg/24 h; 2—4 weeks) causes a significant decrease of total T3 concentration together with a considerable rise of reverse T3 and lower T3-binding capacity. Basal TSH level was increased abouttwice; TSH response to TRH between both groups (without and with Prednison therapy) didnot differ significantly. The observations suggest the presence of hypothyroidism during chronic corticotherapy in children.Keywords
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