RE: "BIASED TESTS OF ASSOCIATION: COMPARISONS OF ALLELE FREQUENCIES WHEN DEPARTING FROM HARDY-WEINBERG PROPORTIONS"

Open Access

1 August 2001

journal article
research article
Published by Oxford University Press (OUP) in American Journal of Epidemiology

Vol. 154 (3) , 287-8
https://doi.org/10.1093/aje/154.3.287

Abstract

The most popular method of analysis in genetic case-control association studies is to compare allele frequencies between cases and controls by using Pearson's chi-square statistic. Sasieni (1) has pointed out that this analysis is appropriate only when Hardy-Weinberg equilibrium holds. Therefore, he recommended using Armitage's trend test (2) instead.

Keywords

ALLELE FREQUENCIES
HARDY WEINBERG
WEINBERG PROPORTIONS
BIASED TESTS

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