Treatment of primary osteoporosis with fluoride and calcium. Clinical tolerance and fracture occurrence

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Abstract
Patients (36) with primary osteoporosis were treated for up to 6 yr with NaF, Ca supplements and, in 24 patients, vitamin D. Major adverse reactions (synovitis, painful plantar fascial syndrome, recurrent vomiting, or anemia) occurred in 15 patients (42%). New vertebral fractures occurred at a rate of 329 fractures/1000 yr of observation. Almost 1/2 occurred during the 1st yr of therapy, and they were only 1/6 as frequent in 12 patients who had fluoride-induced increased trabeculation on vertebral roentgenograms. Until long-term safety and antifracture efficacy are better established, this regimen should continue to be restricted to investigational use.

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