Determination of Certain Drugs in Multicomponent Formulations by First Derivative Ultraviolet Spectrophotometry

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Abstract
The use of 1st derivative spectrophotometry for the simultaneous determination of certain drugs in multicomponent formulations was described. The method was illustrated by the determination of antazoline hydrochloride, phenylephrine hydrochloride and ephedrine hydrochloride in eye drops and acepifylline, phenobarbitone and papaverine hydrochloride in suppositories. These selected applications illustrate the relative ease and simplicity offered by first derivative spectrophotometry for the assay of 3-component mixtures with spectral interferences from matrix formulations.