DIETARY LIPIDS : AN ADDITIONAL REGULATOR OF PLASMA LEVELS OF SEX HORMONE BINDING GLOBULIN

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Abstract
The effect of dietary lipid consumption on plasma levels of sex-hormone binding globulin (SHBG), free testosterone and cholesterol was studied in 6 normal men. After consuming a diet with a high fat content (>100g fat/day) for two weeks, the mean plasma cholesterol level increased (p<0.02) while the mean SHBG level decreased (p<0.02). Changing the diet from one with a high fat to low fat content (<20g fat/day) for a further two week period resulted in a significant reduction in mean plasma cholesterol level (p<0.001) while the mean SHBG level increased (p<0.01). The increase in plasma SHBG was associated with a significant decrease in the free testosterone fraction and free testosterone concentration. No significant changes were detected in plasma samples obtained from the same men during a control period. The results from this study demonstrate that dietary lipid intake is an additional factor involved in the regulation of plasma levels of SHBG.