Analysis of Epitope Spreading over an Eleven-year Period in a Patient with Systemic Lupus Erythematosus: CASE REPORT
- 1 January 1998
- journal article
- case report
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 27 (6) , 461-464
- https://doi.org/10.1080/030097498442316
Abstract
During a period of more than eleven years serum samples of a patient with Systemic Lupus Erythematosus were collected and analyzed for anti-nuclear autoantibodies. High titer of anti-La/SS-B were detectable in all serum samples. The La/SS-B epitopes remained constant. Besides anti-La/SS-B antibodies all serum samples contained traces of anti-Ro/SS-A including anti-Ro52 and anti-Ro60 antibodies. During disease flares anti-Ro/SS-A antibodies were upregulated and anti-dsDNA antibodies appeared, thus supporting the concept of an antigen driven intermolecular epitope spreading to Ro/SS-A and dsDNA.Keywords
This publication has 2 references indexed in Scilit:
- Monoclonal antibodies to the Sjögren's syndrome associated antigen SS-B (La)Journal of Immunological Methods, 1985
- Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with antibodies to Ro and La.Journal of Clinical Investigation, 1982