AN HPLC ASSAY FOR SULFAPYRIDINE IN PLASMA AND ITS USE TO ASSESS SMALL-BOWEL TRANSIT-TIME AFTER THE ADMINISTRATION OF SULFASALAZINE
- 1 July 1987
- journal article
- research article
- Vol. 25 (7) , 406-409
Abstract
An HPLC assay for sulphapyridine is described. The use of the assay to measure sulphapyridine produced by the action of large bowel flora on 2 g of orally administered sulphasalazine as a means of assessing oro-colonic transit time is discussed. The assay is applied to show the action on oro-colonic transit time of a novel gastrokinetic agent BRL 24924 which brought about a 62.8% median reduction in transit time at a dose of 5 mg.This publication has 3 references indexed in Scilit:
- Increased gut cholinergic activity and antagonism of 5‐hydroxytryptamine M‐receptors by BRL 24924: potential clinical importance of BRL 24924British Journal of Pharmacology, 1987
- Effect of gastrointestinal intubation on the passage of a solid meal through the stomach and small intestine in humansGastroenterology, 1983
- Is the transit time of a meal through the small intestine related to the rate at which it leaves the stomach?Gut, 1982