Abstract
There are important similarities between the biology, pathology, and clinical stages of Lyme disease and those of syphilis.1 2 3 4 5 6 7 Both diseases are caused by spirochetes; the Borrelia burg-dorferi that causes Lyme disease and the Treponema pallidum of syphilis are morphologically similar, although the DNA is not homologous.2 In both diseases, the spirochetes can remain alive in human tissue for years. Neuroborreliosis (neurologic Lyme disease) is being called the new "Great Imitator," the name originally attached to syphilis.3

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