Encounters in Space

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Abstract
Cultured cells are known to form focal and fibrillar adhesions with the substrate on which they grow. But to what extent these adhesions represent those formed in vivo is a matter of debate. In a Perspective, Geiger discusses new findings ( Cukierman et al.) claiming that the formation of physiological adhesions depends on the correct combination of molecular composition, topography, and pliability of the matrix.