Differential Host Ranges for in vitro Infectivity of Mouse Mammary Tumour Viruses

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Abstract
Host-range variants of mouse mammary tumor viruses (MMTV) were previously shown to infect cells of several species in vitro productively. Cell lines were identified which exhibit differential restriction for replication of different MMTV variants. A cell line [feline embryo fibroblast FeF] was identified that changes as a function of passage in culture from being permissive to being restrictive to infection with MMTV. MMTV propagated in both murine and nonmurine [human and animal] cells retained their antigenic reactivities in a group-specific radioimmunoassay for MMTV and demonstrated no evidence for the presence of type-C viruses as determined by a variety of techniques. In vitro cell substrate tropisms were established that can be used to differentiate between MMTV.

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