Molecular orchestration of differentiation and function of regulatory T cells
- 1 June 2009
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 23 (11) , 1270-1282
- https://doi.org/10.1101/gad.1791009
Abstract
During the last decade, a unique mechanism of negative regulation of immune responses and inflammation by a dedicated population of so-called regulatory T cells (Treg) has become a focus of intensive investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of differentiation and function of Treg cells, the complex biology of these cells, including maintenance of immunological tolerance to “self” and regulation of immune responses to pathogens, commensals, and tumors, has become amenable to mechanistic studies. In this review, we discuss the molecular aspects of Treg cell lineage commitment, maintenance, and function.Keywords
This publication has 130 references indexed in Scilit:
- Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 ProteinImmunity, 2009
- Differential requirement of PKC-θ in the development and function of natural regulatory T cellsMolecular Immunology, 2008
- TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt functionNature, 2008
- Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen RecognitionPublished by Elsevier ,2008
- Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell RepertoireImmunity, 2008
- A Two-Step Process for Thymic Regulatory T Cell DevelopmentImmunity, 2008
- FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 OncogeneCell, 2007
- Regulatory T cell development in the absence of functional Foxp3Nature Immunology, 2007
- Foxp3 occupancy and regulation of key target genes during T-cell stimulationNature, 2007
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 2006