Effects of DNA-binding drugs on T4 DNA ligase
- 1 March 1990
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 266 (2) , 379-384
- https://doi.org/10.1042/bj2660379
Abstract
A number of DNA intercalating and externally binding drugs have been found to inhibit nick sealing, cohesive and blunt end ligation, AMP-dependent DNA topoisomerization and EDTA-induced DNA nicking mediated by bacteriophage T4 DNA ligase. The inhibition seems to arise from drug-substrate interaction so that formation of active DNA-Mg2(+)-AMP-enzyme complex is impaired while assembled and active complexes are not disturbed by drug binding to the substrate.This publication has 18 references indexed in Scilit:
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