Solubilization of Paracetamol Using Non-Ionic Surfactants and Co-Solubilizers
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 11 (1) , 187-206
- https://doi.org/10.3109/03639048509057678
Abstract
The influence of certain aqueous non-ionic surfactants, cosolvents and cosolvent - surfactant blends on the enhanced solubility of paracetamol were studied. Dielectric constants of these solvent systems with and without paracetamol were determined. In several instances, paracetamol was increased in solubility by 5-7 fold, depending on the system used. Dielectric constants were affected to varying degrees by these systems. The cosolvents, propylene glycol and glycerin apparently suppress micelle formation.This publication has 3 references indexed in Scilit:
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- Cosolubilization in Solutions of Potassium Laurate. The Effect of Cosolubilized Alcohols and Hydrocarbons on the Solubilization of Several Aromatic Compounds in Potassium Laurate Solutions.The Journal of Physical Chemistry, 1951
- Solubilization of Water-Insoluble Dye in Soap Solutions: Effects of Added SaltsJournal of the American Chemical Society, 1946