Inhibition of Growth of HIV by Human Natural Interferon In Vitro

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Abstract
The effect of human natural interferons (IFN) α, β, and γ on the replication of human immunodeficiency virus (HIV) strain LAV in T cell lines TALL-1 and CCRF-CEM and peripheral blood lymphocytes (PBL) was studied. The growth of TALL-1 was moderately sensitive to these IFN, whereas that of CCRF-CEM was resistant to them. The progeny virus yield of LAV in TALL-1 at the time of its peak was reduced to 10% of the control level at IFN-α, β, and γ concentrations of 3, 11, and 23 IU/ml, respectively. These concentrations of IFN-α, β, and γ did not affect the cell growth. In CCRF-CEM, IFN-α, β, and γ at the concentration of 50, 60, and 76 IU/ml reduced the progeny virus to 10% of the control level. The virus growth in PBL was more sensitive to IFN than that in CCRF-CEM. The progeny virus yield was reduced to 10% of the control level by IFN-α and β concentrations of 5 IU/ml and <5 IU/ml, respectively.