INVIVO EFFECT OF DDS ON PHYTOHEMAGGLUTININ (PHA) INDUCED LYMPHOCYTE-TRANSFORMATION CULTURES IN NORMAL HEALTHY-VOLUNTEERS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 47  (2) , 167-170
Abstract
Depression in PHA[phytohemagglutinin]-induced lymphocyte transformation in peripheral blood was observed in 15 healthy [human] volunteers after administration of DDS [4,4-diaminodiphenylsulfone] (100 mg/day) for 7 days. In vitro culture of lymphocytes obtained from these volunteers in DDS-free normal [blood group] AB serum did not alter the blast cell numbers. Lymphocytes of these volunteers contained a significant amount of DDS, ranging from 0.42-3.2 .mu.g/10.6 lymphocytes. [This may explain the slow therapeutic effect of DDS against tuberculosis].