Evaluating Associations between 5-HTTLPR Polymorphism and Alzheimer’s Disease for Korean Patients

1 June 2005

journal article
research article
Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders

Vol. 20 (1) , 31-34
https://doi.org/10.1159/000085071

Abstract

There has been growing evidence that the serotonin (5-HT) system is important in the regulation of memory and thus might be associated with Alzheimer’s disease (AD), while research results on this issue have been inconsistent. The 5-HT system has also been suggested to be responsible for a significant portion of the behavioural aspects of AD. This study aimed to investigate the associations of the 5-HT transporter gene linked polymorphic region (5-HTTLPR) polymorphism with AD and delusional/aggressive symptoms of AD in Korean samples of 65 patients and 43 controls. The 5-HTTLPR polymorphism was neither associated with AD nor with delusional/aggressive symptoms of AD. It was suggested that phenotypic expression of the 5-HTTLPR polymorphism might be varied according to ethnic differences.

Keywords

This publication has 18 references indexed in Scilit:

The 5-HTTPR Polymorphism Confers Liability to a Combined Phenotype of Psychotic and Aggressive Behavior in Alzheimer Disease
International Psychogeriatrics, 2001
The 5-HTTPR*S/*L Polymorphism and Aggressive Behavior in Alzheimer Disease
Archives of Neurology, 2001
A review of the epidemiological transition in dementia — cross‐national comparisons of the indices related to Alzheimer's disease and vascular dementia
Acta Psychiatrica Scandinavica, 2001
Allelic Variation in the Serotonin Transporter Promoter Affects Onset of Paroxetine Treatment Response in Late-Life Depression
Neuropsychopharmacology, 2000
5-HT system and cognition
Neuroscience & Biobehavioral Reviews, 1999
Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimerʼs disease
NeuroReport, 1997
Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene
Journal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1995
Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms
Neurochemical Research, 1992
Possible neurotransmitter basis of behavioral changes in alzheimer's disease
Annals of Neurology, 1988
Clinical diagnosis of Alzheimer's disease
Neurology, 1984