Enzymatic and Chemical Synthesis of 3-Dehydroecdysterone, a Metabolite of the Moulting Hormone of Insects
- 1 January 1977
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 358 (2) , 1339-1344
- https://doi.org/10.1515/bchm2.1977.358.2.1339
Abstract
3-Dehydroecdysterone, a less polar metabolite of ecdysterone, was synthesized in vitro using either an enzyme (ecdysone oxidase, EC 1.1.3.16) or the chemical catalyst Pt. 3-Dehydroecdysterone was purified and characterized by its chromatographic behavior, its staining properties and UV, IR, NMR and mass spectroscopy. The compound is 1/15 as active as ecdysone in the Calliphora molting hormone bioassay. Its biological relevance is discussed.This publication has 12 references indexed in Scilit:
- Catalytical oxidation of ecdysteroids to 3-dehydro products and their biological activitiesJournal of Insect Physiology, 1977
- Ecdysone metabolism and endogenous moulting hormone titre during larval-pupal development in Choristoneura fumiferanaJournal of Insect Physiology, 1976
- Dynamics of ecdysone metabolism after ingestion and injection in Locusta migratoriaGeneral and Comparative Endocrinology, 1976
- A high affinity antiserum specific for the ecdysone nucleusJournal of Insect Physiology, 1976
- Ecdysone Oxidase, an Enzyme from the BlowflyCalliphora erythrocephala(Meigen)Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1975
- Molting hormone titer and metabolic fate of injected ecdysone during the fifth larval instar and in adults of Locusta migratoria (Orthoptera)General and Comparative Endocrinology, 1974
- 3-Dehydroecdyson, ein Stoffwechselprodukt des Ecdysons bei der SchmeißfliegeCalliphora erythrocephalaMeigenHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1972
- DISTRIBUTION AND METABOLISM OF α-ECDYSONE IN PUPAE OF THE SILKWORMANTHERAEA POLYPHEMUSThe Biological Bulletin, 1970
- Der Ecdysontiter während der Insektenentwicklung—I. Eine Methode zur Bestimmung des EcdysongehaltsJournal of Insect Physiology, 1964
- Protonenresonanzspektroskopie und Steroidstruktur I. Das C‐19‐Methylsignal in Funktion der SubstituentenHelvetica Chimica Acta, 1961