STUDIES ON ANEMIA IN F1 HYBRID MICE INJECTED WITH PARENTAL STRAIN LYMPHOID CELLS

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Abstract
Journal of Experimental Medicine.[long dash]The survival of 51Cr-labeled erythrocytes has been studied in F1 hybrid (C57 BL/Ka X BALB/c) mice in which wasting disease was produced by injection of parental lymphoid cells taken either from lymph nodes and thymus or from the spleen. Coincident with the development of the disease syndrome, there occurred a severe anemia accompanied by a sudden loss of circulating labeled erythrocytes, whether host or parental. This finding suggests that the anemia is not due solely to specific immunologic reaction of donor tissue against host erythrocytes.