Copper deficiency and copper toxicity in the rat

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Abstract
Changes in metabolism of an intravenously injected tracer dose of 64Cu were measured in Sprague-Dawley rats subjected to copper loading, by addition of cupric acetate to the drinking water, or made copper deficient, by use of a milk-powder diet and copper-free water. In the copper-deficient rats, hepatic Cu conservation became evident within the 1st few weeks on the regimen; biliary excretion of Cu and 64Cu and plasma oxidase and copper levels promptly decreased. Hepatic copper content decreased only slowly. In copper-laden rats, hepatic copper content increased to high levels but release of biliary 64Cu and ceruloplasmin-64cu by the liver decreased sharply. Urinary excretion of Cu increased. In these respects, the copper-laden rat superficially simulates patients with Wilson''s disease.

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