Metal-Catalyzed Oxidation of Brain-Derived Neurotrophic Factor (BDNF): Analytical Challenges for the Identification of Modified Sites

Abstract
Purpose. We examined the metal-catalyzed oxidation of brain-derivedneurotrophic factor (BDNF) using the Cu(II)/ascorbate/O2 modeloxidative system. Methods. Electrospray ionization mass spectrometry,...