Studies on the inactivation of glyceraldehyde-3-phosphate dehydrogenase by methylglyoxal
- 1 May 1981
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 37 (5) , 443-444
- https://doi.org/10.1007/bf01986121
Abstract
Glyceraldehyde-3-P dehydrogenase (E.C. 1.2.1.12) from rabbit muscle is rapidly inactivated by methylglyoxal following pseudo first-order kinetics. Substrate, as well as inorganic phosphate, affords protection, whereas NAD+ is ineffective. The arginine residue implicated in the reaction is probably the anion binding site of the phosphate group of the substrate.Keywords
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