Synthesis and antibacterial activity of some 3-[(alkylthio)methyl]quinoxaline 1-oxide derivatives
- 1 August 1983
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 26 (8) , 1122-1126
- https://doi.org/10.1021/jm00362a007
Abstract
Some 3-[(alkylthio)methyl]quinoxaline 1-oxide derivatives (1) were synthesized and screened for antibacterial activity. 2-Acetyl-3-[(methylsulfonyl)methyl]quinoxaline 1-oxide (7a) possessed good in vitro activity against some pathogens important to veterinary medicine including Treponema hyodysenteriae a causative agent in swine dysentery [also Escherichia coli, Pasteurella multocida and Salmonella cholerae-suis]. In an in vivo experiment, (7a) completely protected pigs against a swine dysentery challenge over a 21-day period.This publication has 4 references indexed in Scilit:
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