Controlled Trial of P2647 in Elderly Psychiatric Patients

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Abstract
Claimed by the manufacturers as pharmacologically unique, benzquinamide (P2647) is structurally related to reserpine, and to a lesser degree, chlorpromazine (1). It has been demonstrated as markedly suppressing conditioned avoidance responses in animals without influencing the release of central amines, e.g. norepinephrine and serotonin. Animal studies have suggested that this drug is the least sedating of the benzoquinolizine derivatives, acts rapidly and is non-toxic at the recommended dosage levels.