Serum immunoglobulin response in uncomplicated gonorrhoea.

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Abstract
Sera from 225 men and 140 women were examined by an indirect immunofluorescent antibody [Ab] technique for Ab reactive with Neisseria gonorrhoeae. Antigonococcal Ig[immunoglobulin]M was demonstrated at a titer of .gtoreq. 16 in about 45% of infected and 3% of non-infected patients. Most of this Ab occurred in sera of patients who were infected for less than 14 days. Antibody of the IgA class was found at a titer of .gtoreq. 16 in over half the infected but in none of the non-infected patients. IgG Ab reactive with the gonococcus was found in each infected patient at a titer of .gtoreq. 16 and 8% in controls. The mean log titer of this Ab was significantly higher in patients who had been infected for more than 7 days than in those whose infection was of shorter duration.