Streptococci deficient in genetic transformation

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Abstract
Three strains of group H streptococci have been found to produce competence factors (CF's) similar to that synthesized by the highly transformable strain Challis. All these factors efficiently converted to competency for DNA uptake the spontaneously nontransformable strain Wicky. Two of the three strains could be transformed to drug resistance with an extremely low efficiency and one strain was nontransformable. When the bacteria were exposed to tritium-labeled DNA, it was found that a viable unit of the three strains contained about 10 times less radioactivity than a viable unit of Challis and Wicky in the competent state. The probability that CF may not be the only factor required for DNA uptake is discussed.

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