DOSE-RESPONSE BETWEEN EXOGENOUS CORTISONE ACETATE AND THE URINARY EXCRETION OF TRYPSIN INHIBITOR IN MAN

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Abstract
The effect of different doses of exogenous cortisone acetate on the urinary excretion of trypsin inhibitor was studied in 3 women with approximately the same normal spontaneous 24-hour cortisol production. No correlation could be found between the dose of cortisone and the crude trypsin inhibitor excretion produced. However, when the 24-hour trypsin inhibitor excretion on the day of hormone administration was measured with the subject''s normal spontaneous 24-hour excretion level of the inhibitor as unit, a high degree of positive correlation (direct proportionality) was found. These results can be explained by the previously proposed theory, that the urinary trypsin inhibitor excretion is determined by the equation: Excretion of trypsin inhibitor - Amount of glucocorticoid affecting the organism X Sensitivity to glucocorticoid, where sensitivity to glucocorticoid is the excretion of trypsin inhibitor produced by 1 mg of the glucocorticoid.