Synthesis and Antiherpetic Activities of Several Acyclic Analogues Of Guanosine
- 1 June 1991
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (4) , 739-753
- https://doi.org/10.1080/07328319108046659
Abstract
Several acyclic analogues of guanosine, 2′-deoxy-2′, 3′-secoguanosine(3), 3′-deoxy-2′, 3′-secoguanosine (4), and 2′-, 3′-dideoxy-2′-, 3′-secoguanosine were synthesized from guanosine. In addition, the 3′-, 5′-cyclic phosphate (21) and 3′-, 5′-cyclic methylphosphonates (22a, b) of 3 were also prepared. At concentrations up to 300 μM none of these compounds had significant antiherpetic activity in antiviral assays in vitro.Keywords
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