PROLONGATION OF HETEROTOPIC CARDIAC ALLOGRAFTS IN DOGS BY TOPICAL RADIATION

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Abstract
SUMMARY The effect of topical radiation on heterotopically transplanted cardiac allografts has been investigated in dogs. Seventy-three transplants were done in this series, with 10 animals serving as controls, and the remaining 63 receiving 2400-rad radiation to the graft in 6 equal doses, over a period of 3 weeks. Seventy-five per cent of the radiated grafts maintained viability for periods up to 10 weeks, while 90% of the nonradiated transplants were rejected by the 12th postoperative day. In addition, 12 intact canine hearts radiated with identical dose and fractionation provided histological controls for the radiated transplanted group. Electrocardiographic changes and alteration in lactic dehydrogenase values proved to be the most sensitive parameters of early rejection.

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