Oxidant signalling in carcinogenesis: a commentary
Open Access
- 1 February 2002
- journal article
- research article
- Published by SAGE Publications in Human & Experimental Toxicology
- Vol. 21 (2) , 63-64
- https://doi.org/10.1191/0960327102ht211oa
Abstract
It is becoming increasingly evident that reactive oxygen species (ROS) act at different stages of carcinogenesis, and thus play multiple roles in oncogenesis. In addition to being mutagenic and initiating tumors, ROS or carcinogens that result in ROS generation may affect tumor promotion and progression through varied effects on growth promoting, growth inhibitory, or apoptotic signaling pathways.Keywords
This publication has 5 references indexed in Scilit:
- 2-Acetylaminofluorene Up-regulates Rat mdr1bExpression through Generating Reactive Oxygen Species That Activate NF-κB PathwayPublished by Elsevier ,2001
- Protein kinase C signaling and oxidative stressFree Radical Biology & Medicine, 2000
- Activator protein 1 (AP-1)– and nuclear factor κB (NF-κB)–dependent transcriptional events in carcinogenesisFree Radical Biology & Medicine, 2000
- Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell linesCarcinogenesis: Integrative Cancer Research, 1999
- Mitogenic Signaling Mediated by Oxidants in Ras-Transformed FibroblastsScience, 1997