Dissociation of MNSs Antigens Using Sodium Deoxycholate Fraction of Erythrocyte Membranes
- 1 March 1975
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 28 (3) , 200-206
- https://doi.org/10.1111/j.1423-0410.1975.tb02758.x
Abstract
A dissociation of the MNSs blood group system has been demonstrated by sodium deoxycholate fractionation of erythrocyte membrane preparations. The MN antigens were localized in a fraction that sedimented at 30,000 g while the Ss antigens remained soluble after 100,000 g centrifugation for donors who were heterozygous at the MN locus. In contrast, fractions derived from erythrocytes of 'homozygous' M or N donors showed M or N activity in both the 30,000 g pellet and 100,000 g supernatant and Ss remained in the 100,000 g supernatant.Keywords
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