CORRELATION BETWEEN IMMUNOADJUVANT ACTIVITIES AND PYROGENICITIES OF SYNTHETIC N-ACETYLMURAMYL-PEPTIDES OR N-ACETYLMURAMYL-AMINO ACIDS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 19  (1) , 9-13
Abstract
A total of 14 different N-acetylmuramyl-peptides or -amino acids with or without configurations inherent to bacterial cell wall peptidoglycans were synthesized and their pyrogenicities on i.v. injection into rabbits were tested. N-Acetylmuramyl-peptides, and especially N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-lysine, which were previously shown to be adjuvant-active in induction of delayed-type hypersensitivity and stimulation of increased serum antibody levels to ovalbumin in guinea pigs, exhibited distinct pyrogenicity at as low a dose as 16 .mu.g/rabbit. None of the adjuvant-inactive analogues or diastereomers of the above N-acetylmuramyl-dipeptide or related compounds caused any significant febrile response in rabbits, even at a dose of 250 .mu.g/animal.

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