PATHOPHYSIOLOGICAL AND BIOCHEMICAL CHANGES IN ANTHRAX

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Abstract
Pathophysiological and biochemical changes in anthrax are reviewed. The comparison between spore- and toxin-challenged animals shows a remarkable similarity, indicating that the toxin of Bacillus anthracis caused death although the organisms per se caused little pathophysiological response. Death was primarily due to a respiratory depression of central nervous system origin; the cardiovascular system remained intact. Death occurred with an extreme anoxia that was accompanied late in the disease by numerous secondary or nonspecific changes in the blood cellular, chemical, and gaseous elements.

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