Serum ferritin, liver iron stores, and liver histology in children with thalassaemia.
Open Access
- 1 January 1980
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 55 (1) , 43-45
- https://doi.org/10.1136/adc.55.1.43
Abstract
Serum ferritin, liver iron stores, and liver histology were studied in 38 children with thalassaemia major who were being treated by regular blood transfusions. There was no correlation between serum ferritin levels and either the number of transfusions or the amount of iron deposited in the liver. However, for a given level of iron stores, ferritin levels were higher in patients with chronic hepatitis (including chronic aggressive and chronic persistent forms) than in those with hepatic siderosis only. We conclude that serum ferritin reflects tissue iron deposits in regularly transfused thalassaemic patients, only in the absence of hepatitis.Keywords
This publication has 12 references indexed in Scilit:
- Serum ferritin and iron stores.1977
- Total management of thalassaemia major.Archives of Disease in Childhood, 1977
- Role of chronic hepatitis in development of thalassaemic liver disease.Archives of Disease in Childhood, 1976
- Measurement of serum ferritin by a 2-site immunoradiometric assayAnalytical Biochemistry, 1974
- Serum ferritin in children with thalassaemia regularly transfusedJournal of Clinical Pathology, 1974
- A Clinical Evaluation of Serum Ferritin as an Index of Iron StoresNew England Journal of Medicine, 1974
- Ferritin in the Serum of Normal Subjects and Patients with Iron Deficiency and Iron OverloadBMJ, 1972
- An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overloadJournal of Clinical Pathology, 1972
- Globin chain synthesis in the alpha thalassemia syndromesJournal of Clinical Investigation, 1968
- A CLASSIFICATION OF CHRONIC HEPATITISThe Lancet, 1968